There's no Savebutton in Illustrator, as far as I know. Use the Save menu command. If it doesn't work, then there sure is something strange happening. Please add extra information and/or screen shots, because this isn't normal.
Help: How to save a file for output.
Oorspronkelijk geplaatst op Quora: How do you save files in Adobe Illustrator because the save button does not work?"